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Cirrhosis
 

How are you going to manage this patients cirrhosis?

I’m glad you asked me that (notice the fantastic mnemonic),

Prognosis – pattern/ activity/ severity, Childs Score
Origin - ?Hepatitis ?specific therapy available(*)
Rehabilitation – Alcohol, other
Transplant – Assessment
Ascites – Consider norfloxacin, paracentesis, Salt restriction, Aldactone, Frusemide, TIPPS, monitor weight/ EUCs
Lifestyle – Including nutrition, multivitamin, recommendations to prevent transmission

Varices – Non-selcetive beta-blocker, banding
Encephalopathy – Treat reversible factors, lactulose
Infection – Vaccinate
Neoplasia – Screen with aFP/ CT (Ultrasound only 60% sensitive)

(*)    Hepatitis B  -    treat with interferon if histologic chronic hepatitis with high ALT and low HBV DNA levels, not effective for pre-core mutant infection
                           -    Same indications for lamivudine, works for pre-core mutant and YMDD mutant

        Hepatitis C   -    Treat if persistently elevated ALT
                            -    Positive HCV RNA
                            -    Liver Biopsy showing moderate inflammation/ necrosis
                            -    Compensated Cirrhosis
                            -    Consider if persistently elevated ALT with minimal or mild histological changes

Remember that depression, autoimmune disease and pancytopenia are relative contra-indications. A low viral load and genotypes 2,3 are associated with an increased response rate. Therapy duration is tailored to prognosis.

Another simple way to remember things is to group the points above is into;
            Preventative measures,
            Definitive treatment measures
            Issues related to complications